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BEVACIZUMAB 400MG INJECTION (BRYXTA)
DESCRIPTION
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PACKAGE
OVERVIEW & USAGE
Overview
Bryxta injection is a prescription drug. It is used in the treatment of patients with colorectal cancer, glioblastoma multiforme, renal cell carcinoma, cervical cancer, ovarian cancer, and other types of cancers. It can be prescribed either alone or in combination with other medications. This medicine can be used as a first-line treatment for certain cancers when used in combination. It comprises Bevacizumab, which is thought to be an effective regimen for the treatment of COVID-19 patients also. This medication works by hindering the growth of new blood vessels that are responsible for feeding the tumors. Through this mechanism, Bryxta stops the tumor’s growth. Bryxta (Bevacizumab) is available in the form of injections with strengths of 100mg and 400mg.
Pharmacodynamics
The active ingredient of Bryxta injection works to bind VEGF or circulating vascular endothelial-derived growth factor. Bevacizumab works by blocking it from binding to its consequent receptors while effectively blunting downstream signaling. The effects caused by this ingredient have been presented to re-establish normal vasculature at the tumor site that caused an increase in nutrient and oxygen supply. Bryxta injection also improves the delivery of chemotherapeutic agents to the target region. On the other hand, VEGF signaling is a critical constituent of different processes such as coagulation, healing of the wound, angiogenesis, regulation of BP, and renal filtration. Though blocking VEGF may cause inhibition of metastatic disease progression, it can also cause certain unwanted events because of the role of VEGF in various other physiologic mechanisms.
Interactions
Medicine Interactions
- Sunitinib
- Topotecan
- Pamidronate
- Risedronate
- Deferiprone
- Palifermin
Disease Interactions
- Gastrointestinal perforation
- Bleeding
- Hypertension
- Proteinuria
Alternate Brands
- Abevmy 400mg Injection
- Krabeva 400mg Injection
- Bevacirel 400mg Injection
- Avastimab 400mg Injection
- Avastin 400mg Injection
Contraindications
Bryxta (Bevacizumab) injection should not be administered in the following cases:-
- Hypersensitivity
- A known allergy to Bevacizumab
- Surgeries
Side Effects
Bryxta (Bevacizumab) injection can cause certain side effects. The following are a few of them:-
- Bleeding gums
- Vomiting
- Diarrhea
- Seizures
- Unusual bleeding
- Nose bleeds
- Dry skin
- Hypertension
- Shortness of breath
- Irregular heartbeat
- Taste change
- Swelling of the feet
- Cough
- Dizziness
- Loss of appetite
- Body pain
- Runny nose
- Fatigue
- Nasal congestion
- Pale skin
- Headache
- Anxiety
- Blood clots
- Chest pain
- Sore throat
- Fever
- High blood pressure
- Protein in urine
- Decreased white blood cell count
Note:- Do not ignore any of the side effects. Consult a healthcare provider.
Dosage
Normal Dose
Bryxta (Bevacizumab) injection is given to the patient by a nurse. This injection is administered as an infusion. Do not self-administer.
Missed Dose
If you skip a dose of Bryxta (Bevacizumab) injection, make sure to schedule another appointment with your doctor. Do not try to cope with the missed dose by administering the injection on your own.
Overdose
Overdose may not be possible as the injection is given by a nurse. However, if an overdose occurs, consult a healthcare provider immediately.
Warnings And Precautions
Before starting the treatment with Bryxta (Bevacizumab) injection, it is absolutely important to make the healthcare team aware of the medical history and the current health condition.
Warnings For Females
- Pregnancy
Use of Bryxta (Bevacizumab) injection is not recommended in pregnant women unless its administration becomes absolutely necessary.
- Breastfeeding
Use of Bryxta (Bevacizumab) injection is not recommended in nursing women unless its administration becomes absolutely necessary.
Precautions
- Contraception
Use of effective contraceptives is advised to patients receiving treatment with Bryxta (Bevacizumab) injection.
- Children
Due to the presence of Bevacizumab in Bryxta injection, it may not be safe for use in children.
Cautions
- Do not self-administer Bryxta (Bevacizumab) injection.
- Alcohol consumption may not be safe for patients receiving Bryxta (Bevacizumab) injection.
- Avoid driving after receiving Bryxta (Bevacizumab) injection.
- Do not freeze Bryxta injection.
- Do not skip a dose of Bryxta (Bevacizumab) injection or overdose.
